Cloperastine hydrochloride

CAS No. 14984-68-0

Cloperastine hydrochloride( —— )

Catalog No. M12081 CAS No. 14984-68-0

Cloperastine hydrochloride is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cloperastine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cloperastine hydrochloride is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance.
  • Description
    Cloperastine hydrochloride is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance.(In Vitro):Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with an IC50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.(In Vivo):In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width.Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    HT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    14984-68-0
  • Formula Weight
    366.33
  • Molecular Formula
    C20H25Cl2NO
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in DMSO
  • SMILES
    Cl.ClC1=CC=C(C=C1)C(OCCN1CCCCC1)C1=CC=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yu MC, et al. Eur J Pharmacol, 2010, 627(1-3), 269-275.
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